物质信息
ID:351914
名称和标识
IUPAC标准名
(2S)-2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
别名
5-Fluoro-L-tryptophan
IUPAC传统名
fluorotryptophane
化合物性质
产品相关信息
纯度
≥98.0% (HPLC)
Empirical Formula (Hill Notation)
C11H11FN2O2
光学纯度
enantiomeric ratio: ≥99.5:0.5 (HPLC)
安全信息
保存温度
2-8°C
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
MSDS下载
德国WGK号
3
描述信息
Application
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis3. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR4.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp.1 However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.2
Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis3. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR4.
Biochem/physiol Actions
5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp.1 However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity.2
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