物质信息
ID:351248
名称和标识
IUPAC传统名
trimethoprim
IUPAC标准名
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
别名
2,4-二氨基-5-(3,4,5-三甲氧基苄基)嘧啶甲氧苄啶Trimethoprim2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
化合物性质
安全信息
保存温度
2-8°C
MSDS下载
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECS编号
UV8225000
德国WGK号
3
产品相关信息
纯度
≥99.0% (HPLC)
Empirical Formula (Hill Notation)
C14H18N4O3
品质说明
crystallized
理化性质
溶解度
chloroform/ethanol (1:1): soluble50 mg/mL, clear, colorless
熔点
199-203 °C
药理学性质
相关基因信息
human ... DHFRP1(573971), KCNH1(3756)rat ... Dhfr(24312)
描述信息
Application
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.
Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis 1 and mechanism of resistance studies in Haemophilus influenzae 2.
Biochem/physiol Actions
Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).
Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Other Notes
Specific inhibitor of formulation. Widely used in studies on dihydrofolate reductase3,4.
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