物质信息
ID:351036
名称和标识
别名
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-oneAlsterpaullone
IUPAC传统名
alsterpaullone
IUPAC标准名
14-nitro-8,18-diazatetracyclo[9.7.0.02,7.012,17]octadeca-1(11),2,4,6,12,14,16-heptaen-9-one
化合物性质
理化性质
外观
yellow to brown powder
溶解度
DMSO: ≥10 mg/mL
安全信息
危险公开号
36/37/38
MSDS下载
保存温度
2-8°C
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
德国WGK号
3
GHS危险声明
H315-H319-H335
保存条件
desiccated
欧盟危险性物质标志
刺激性 (Xi)个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
安全公开号
26-36
GHS警示词
Warning
GHS警示性声明
P261-P305+P351+P338
药理学性质
相关基因信息
rat ... Gsk3b(84027)
产品相关信息
Empirical Formula (Hill Notation)
C16H11N3O3
纯度
≥98% (HPLC)
描述信息
Biochem/physiol Actions
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.
Potent and selective inhibitor of GSK-3β and CDK5/p25; potent inhibitor of CDK1/cyclin B (IC50 = 0.035 μM).
Application
Alsterpaullone inhibits GSK-3β, CDK5/p25, and CDK1/cyclin B. Alsterpaullone has also been studied as an antimanic therapeutic for the acute manic phase of bipolar disorder.
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