物质信息
ID:349539
名称和标识
IUPAC传统名
ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
IUPAC标准名
ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
别名
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl esterEthyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylateAI-1
化合物性质
安全信息
MSDS下载
GHS警示性声明
P280
欧盟危险性物质标志
刺激性 (Xi)GHS危险声明
H317
危险公开号
43
保存温度
2-8°C
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示词
Warning
安全公开号
36/37
产品相关信息
Empirical Formula (Hill Notation)
C13H12ClNO3
纯度
≥98% (HPLC)
理化性质
外观
white to tan powder
溶解度
DMSO: ≥15 mg/mL
描述信息
Biochem/physiol Actions
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.
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