物质信息
ID:349277
名称和标识
IUPAC传统名
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
IUPAC标准名
N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
别名
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamidePD 0325901
化合物性质
产品相关信息
纯度
≥98% (HPLC)
Empirical Formula (Hill Notation)
C16H14F3IN2O4
安全信息
GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
急性毒性（口服，皮肤接触，吸入），类别1,2,3
对水环境的危害
急性危害，类别1
慢性危害，类别1,2
MSDS下载
GHS警示性声明
P273-P301+P310-P501
GHS危险声明
H301-H373-H410
欧盟危险性物质标志
环境危害性 (N)
有毒 (T)保存温度
2-8°C
危险公开号
25-48-50
安全公开号
22-36/37/39-61
GHS警示词
Danger
德国WGK号
3
理化性质
比旋光度
[α]/D -1.8 to -3.0°, c = 1 mg/mL in methanol
外观
white to off-white powder
溶解度
DMSO: ≥20 mg/mL
描述信息
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
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