物质信息
ID:349089
名称和标识
IUPAC传统名
naphtho[1,2-d][1,3]thiazol-2-amine
IUPAC标准名
naphtho[1,2-d][1,3]thiazol-2-amine
别名
SKA-31Naphtho[1,2-d]thiazol-2-ylamine
化合物性质
安全信息
欧盟危险性物质标志
有害性 (Xn)安全公开号
26
危险公开号
22-36
MSDS下载
保存温度
-20°C
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS危险声明
H302-H319
GHS警示性声明
P305+P351+P338
GHS警示词
Warning
产品相关信息
纯度
≥98% (HPLC)
Empirical Formula (Hill Notation)
C11H8N2S
理化性质
溶解度
DMSO: ≥30 mg/mL
外观
solid
描述信息
Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.
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