物质信息
ID:349025
名称和标识
IUPAC标准名
4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
IUPAC传统名
razoxane
别名
Razoxane1,2-Bis(3,5-dioxo-1-piperazinyl)propaneICRF 159TroxozoneNSC 129943RazoxinTepirone(±)-1,2-Bis(3,5-dioxopiperazinyl)propane4,4′-Propylenebis(2,6-piperazinedione)(±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propaneICI 59118
化合物性质
理化性质
溶解度
DMSO: soluble40 mg/mL
外观
solid
安全信息
产品相关信息
Empirical Formula (Hill Notation)
C11H16N4O4
纯度
>98% (HPLC)
描述信息
Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.
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