物质信息
ID:348890
名称和标识
IUPAC标准名
2-hexadecanamidoacetic acid
IUPAC传统名
N-palmitoyl glycine
别名
PalGlyHexadecanoylaminoacetic acidN-palmitoyl glycine
化合物性质
安全信息
德国WGK号
2
MSDS下载
个人保护装置
Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
保存温度
2-8°C
产品相关信息
纯度
≥98% (HPLC)
Empirical Formula (Hill Notation)
C18H35NO3
理化性质
溶解度
DMSO: >10 mg/mL
外观
white to off-white solid
描述信息
Biochem/physiol Actions
PalGly is an endogenous signaling lipid that modulates calcium influx and nitric oxide production. PalGly inhibits heat-evoked firing of wide dynamic range (WDR) neurons, activates calcium influx in DRG cells and stimulates NO production. Preliminary studies suggest its signaling mechanism involves GPCR-mediated cation channel activation and a Gαi/o-coupled signaling pathway, which is being further investigated.
PalGly is an endogenous signaling lipid that modulates calcium influx and nitric oxide production. PalGly inhibits heat-evoked firing of wide dynamic range (WDR) neurons, activates calcium influx in DRG cells and stimulates NO production. Preliminary studies suggest its signaling mechanism involves GPCR-mediated cation channel activation and a Gαi/o-coupled signaling pathway, which is being further investigated.
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