物质信息
ID:348442
名称和标识
IUPAC传统名
(2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid
IUPAC标准名
(2S,3R)-2-amino-4-hydroxy-3-methylpentanoic acid
别名
4-HYDROXYISOLEUCINE(4S)-4-Hydroxy-L-isoleucineHIL(2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid
化合物性质
理化性质
闪点
296.6 °F
147 °C
比旋光度
[α]/D +31.0±1.5°, c = 1 in H2O
安全信息
保存温度
2-8°C
GHS警示词
Warning
欧盟危险性物质标志
刺激性 (Xi)GHS警示性声明
P261-P305+P351+P338
德国WGK号
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS危险声明
H315-H319-H335
安全公开号
26
MSDS下载
危险公开号
36/37/38
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
产品相关信息
Empirical Formula (Hill Notation)
C6H13NO3
纯度
≥98.0% (TLC)
生物来源
from fenugreek seed
描述信息
Biochem/physiol Actions
(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.
4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.
(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.
4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.
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