物质信息
ID:348334
名称和标识
IUPAC传统名
adefovir dipivoxil
IUPAC标准名
[({[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}({[(2,2-dimethylpropanoyl)oxy]methoxy})phosphoryl)oxy]methyl 2,2-dimethylpropanoate
别名
9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenineAdefovir dipivoxil
化合物性质
安全信息
MSDS下载
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
保存温度
-20°C
安全公开号
36/37
GHS警示词
Warning
欧盟危险性物质标志
有害性 (Xn)GHS危险声明
H302-H312-H332
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
GHS警示性声明
P280
危险公开号
20/21/22
德国WGK号
3
产品相关信息
Empirical Formula (Hill Notation)
C20H32N5O8P
描述信息
Biochem/physiol Actions
Antiviral acyclic nucleoside phosphonate (ANP) analog.
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog.that works by blocking reverse transcriptase 3. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification 4. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1) 5. Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages 2.
Application
Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment 1,2.
Antiviral acyclic nucleoside phosphonate (ANP) analog.
Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analog.that works by blocking reverse transcriptase 3. It is an inhibitor of duck hepatitis B virus (DHBV) replication that inhibits covalently closed circular DNA (CCC DNA) amplification 4. Cytotxicity is induced by Human Renal Organic Anion Transporter 1 (hOAT1) 5. Adefovir is an Inhibitor of edema factor (EF)-induced cAMP accumulation and changes in cytokine production in mouse primary macrophages 2.
Application
Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment 1,2.
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