物质信息
ID:348260
名称和标识
IUPAC标准名
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorobenzenesulfonyl)-2-hydroxy-2-methylpropanamide
别名
CosudexCasodexN-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamideBicalutamide (CDX)
IUPAC传统名
bicalutamide
化合物性质
安全信息
德国WGK号
3
GHS危险声明
H315-H319-H335
保存条件
protect from light
desiccated
GHS警示词
Warning
MSDS下载
GHS警示性声明
P261-P305+P351+P338
安全公开号
26
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
危险公开号
36/37/38
RTECS编号
TX1413500
欧盟危险性物质标志
刺激性 (Xi)个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
理化性质
外观
powder
溶解度
H2O: insoluble
DMSO: >5 mg/mL
产品相关信息
Empirical Formula (Hill Notation)
C18H14F4N2O4S
纯度
≥98% (HPLC)
描述信息
Biochem/physiol Actions
Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.
Bicalutamide (CDX) is a non-steriodal Androgen Receptor (AR) antagonist and a pure antiandrogen. It acts via balancing histone acetylation/deacetylation and recruitment of coregulators. Bicalutamide (CDX) abolishes androgen-mediated expression. For example, MMP13 upregulation in prostate cancer, PLZF (promyelocytic leukemia zinc finger protein), and GADD45γ (growth arrest and DNA damage inducible, gamma). Bicalutamide (CDX) is inhibited by non-genomic, transcription-independent stimulation of PI3K/AKT phosphorylation by androgens.
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