物质信息
ID:348190
名称和标识
别名
CFTR(inh)-1725-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone
IUPAC标准名
4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid
IUPAC传统名
4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid
化合物性质
产品相关信息
纯度
≥98% (HPLC)
Empirical Formula (Hill Notation)
C18H10F3NO3S2
理化性质
溶解度
H2O: insoluble
DMSO: ≥10 mg/mL
外观
yellow powder
安全信息
欧盟危险性物质标志
环境危害性 (N)
刺激性 (Xi)MSDS下载
GHS警示性声明
P261-P273-P280-P305+P351+P338-P501
联合国危险货物包装类别(PG)
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
对水环境的危害
急性危害，类别1
慢性危害，类别1,2
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示词
Warning
安全公开号
26-36/37-60-61
联合国危险货物等级
9
德国WGK号
3
GHS危险声明
H315-H317-H319-H335-H410
保存温度
2-8°C
联合国危险货物编号
3077
RID/ADR
UN 3077 9/PG 3
危险公开号
36/37/38-43-50/53
描述信息
Biochem/physiol Actions
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.
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