物质信息
ID:315376
名称和标识
别名
对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物氟安定 水合物L-氨甲喋呤 水合物氨甲喋呤 水合物甲氨蝶呤 水合物MTX 水合物氨甲叶酸 水合物L-Amethopterin hydrateMTX hydrateMethotrexate hydrateL-氨甲喋呤 水合物4-Amino-10-methylfolic acid hydrateL-4-Amino-N10-methylpteroylglutamic acid hydrateAntifolan hydrateL-Amethopterin hydrateMethylaminopterin hydrate
IUPAC传统名
hydrate methotrexate
IUPAC标准名
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
化合物性质
安全信息
GHS警示词
Danger
联合国危险货物等级
6.1
联合国危险货物编号
1544
德国WGK号
3
联合国危险货物包装类别(PG)
3
GHS危险声明
H301-H315-H319-H360
RID/ADR
UN 1544 6.1/PG 3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
MSDS下载
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明
P201-P301+P310-P305+P351+P338-P308+P313
危险公开号
61-25-36/38
安全公开号
53-26-36/37-45
欧盟危险性物质标志
有毒 (T)药理学性质
相关基因信息
human ... DHFRP1(573971), FPGS(2356), SLC19A1(6573), TYMS(7298)mouse ... Dhfr(13361)rat ... Dhfr(24312)
产品相关信息
纯度
98%
Empirical Formula (Hill Notation)
C20H22N8O5 · xH2O
理化性质
比旋光度
[α]25/D +17°, c = 1 in 0.05 M Na2CO3
描述信息
包装
100 mg in glass bottle
Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
二氢叶酸还原酶的强效抑制剂1，以及用于抗癌抗菌素研究的试剂。2,3
100 mg in glass bottle
Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
二氢叶酸还原酶的强效抑制剂1，以及用于抗癌抗菌素研究的试剂。2,3
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参考文献
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