Drug Groups

approved

Description

An antipsychotic agent used in schizophrenia. [PubChem]

Indication

For the management of the manifestations of psychotic disorders such as schizophrenia

Pharmacology

Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established, however, it is believed that by antagonising dopamine and serotonin receptors, there is a marked cortical inhibition which can manifest as tranquilization and suppression of aggression.

Toxicity

LD₅₀=65 mg/kg (Orally in mice)

Affected Organisms

Biotransformation

Hepatic

Absorption

Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers

Half Life

Oral-4 hours

Elimination

Metabolites are excreted in the urine in the form of conjugates and in the feces unconjugated.

References

External Links