Drug Groups

approved

Description

A benzenesulfonamide-phthalimidine that tautomerizes to a benzophenones form. It is considered a thiazide-like diuretic. [PubChem]

Indication

For management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Pharmacology

Chlorthalidone, a monosulfonamyl diuretic, differs form other thiazide diuretics in that a double ring system is incorporated into its structure. Chlorthalidone is used alone or with atenolol in the management of hypertension and edema.

Toxicity

Symptoms of overdose include nausea, weakness, dizziness and disturbances of electrolyte balance.

Affected Organisms

Biotransformation

Liver

Absorption

Absorbed relatively rapidly after oral administration.

Half Life

40 hours

Protein Binding

High (75% [58% to albumin])

Elimination

The major portion of the drug is excreted unchanged by the kidneys.

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