物质信息
ID:184314
名称和标识
别名
1-甲基-3-异丁基黄嘌呤3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮3-异丁基-1-甲基黄嘌呤3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮3-Isobutyl-1-methylxanthineIBMX
IUPAC传统名
3 isobutyl 1 methylxanthine
IUPAC标准名
1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
化合物性质
药理学性质
相关基因信息
rat ... Adora1(29290), Adora2a(25369)
产品相关信息
痕量阴离子
sulfate (SO42-): <0.05%
痕量阳离子
Fe: <0.005%
K: <0.05%
Al: <0.0005%
Cu: <0.0005%
Pb: <0.001%
Ca: <0.005%
Zn: <0.0005%
NH4+: <0.05%
Mg: <0.005%
Na: <0.005%
燃烧残渣
<0.1%
纯度
≥99%
杂质
<0.005% Phosphorus (P)
安全信息
GHS危险声明
H302
RTECS编号
ZD8500000
德国WGK号
3
保存温度
-20°C
危险公开号
22
GHS警示词
Warning
欧盟危险性物质标志
有害性 (Xn)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
个人保护装置
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
理化性质
熔点
200-201 °C(lit.)
描述信息
Biochem/physiol Actions
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1
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