物质信息
ID:184259
名称和标识
IUPAC标准名
(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
IUPAC传统名
deoxyglucose
别名
2-脱氧-D-葡糖D-2-脱氧葡萄糖2-Deoxy-D-glucose
化合物性质
产品相关信息
痕量阳离子
Zn: ≤0.0005%
Cu: ≤0.0005%
Na: ≤0.005%
Ca: ≤0.003%
Fe: ≤0.0005%
K: ≤0.005%
Pb: ≤0.001%
NH4+: ≤0.05%
Al: ≤0.0005%
Mg: ≤0.0005%
杂质
<0.1% Insoluble matter
≤0.001% Phosphorus (P)
痕量阴离子
sulfate (SO42-): ≤0.05%
chloride (Cl-): ≤0.05%
燃烧残渣
<0.1%
纯度
≥98%
安全信息
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
德国WGK号
3
理化性质
熔点
146-147 °C(lit.)
溶解度
H2O: soluble1 M at 20 °C, clear, colorless
描述信息
Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
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