物质信息
ID:183827
名称和标识
IUPAC标准名
benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
IUPAC传统名
benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
别名
Z-Leu-Leu-NorvalinalMG115Z-LLnV
数据登录号
CAS号
化合物性质
药理学性质
相关基因信息
human ... PSMA1(5682), PSMC1(5700)mouse ... PSMA1(26440), PSMC1(19179)rat ... PSMA1(29668), PSMC1(117263)
安全信息
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
德国WGK号
3
保存温度
-20°C
理化性质
外观
white powder
溶解度
DMSO: soluble
产品相关信息
纯度
≥90% (HPLC)
描述信息
Amino Acid Sequence
Z-Leu-Leu-Nva
Biochem/physiol Actions
Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
Z-Leu-Leu-Nva
Biochem/physiol Actions
Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
分子图谱
暂无数据
点击上传数据
参考文献
暂无数据
点击上传数据