物质信息
ID:183432
名称和标识
IUPAC标准名
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
IUPAC传统名
kaempferol
别名
Robigenin3,4′,5,7-Tetrahydroxyflavone3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneKaempferol
化合物性质
安全信息
安全公开号
36/37-45
保存条件
protect from light
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
个人保护装置
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS警示性声明
P281-P301+P310
德国WGK号
3
危险公开号
25-68
欧盟危险性物质标志
有毒 (T)GHS警示词
Danger
GHS危险声明
H301-H341
保存温度
room temp
药理学性质
相关基因信息
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)mouse ... Hexa(15211)
理化性质
外观
yellow powder
溶解度
ethanol: soluble20 mg/mL
DMSO: soluble50 mg/mL
产品相关信息
纯度
≥90% (HPLC)
描述信息
Application
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1
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参考文献
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