Other Notes
Nalidixic acid analog with broad-spectrum antibacterial activity.
Application
Ofloxacin is a synthetic fluoroquinolone with broad-spectrum antibacterial activity. It is a nalidixic acid analog. It is given to patients before undergoing retinal reattachment surgery1. It is used to study pneumococcal cell wall-degrading virulence factors2.
Biochem/physiol Actions
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, which haults DNA replication and cell division. Ofloxacin has been shown to convert LytA from the inactive E-form to the active C-form2. It is a chiral molecule that inhibits pneumococcal cell wall-degrading virulence factors2.