物质信息
ID:183157
名称和标识
IUPAC传统名
dicoumarol
IUPAC标准名
4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
别名
3,3′-Methylene-bis(4-hydroxycoumarin)DicumarolDicoumarol
化合物性质
安全信息
GHS危险品标识
对水环境的危害
急性危害，类别1
慢性危害，类别1,2
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
欧盟危险性物质标志
环境危害性 (N)
有毒 (T)GHS警示性声明
P273-P314
危险公开号
22-48/25-51/53
GHS危险声明
H302-H372-H411
个人保护装置
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS编号
GN7875000
RID/ADR
UN 2811 6.1/PG 3
联合国危险货物编号
2811
GHS警示词
Danger
联合国危险货物等级
6.1
联合国危险货物包装类别(PG)
3
德国WGK号
3
安全公开号
37-45-61
药理学性质
相关基因信息
human ... CYP2C9(1559)
理化性质
熔点
290-292 °C(lit.)
描述信息
Biochem/physiol Actions
Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one1, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.
Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one1, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.
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