物质信息
ID:182973
名称和标识
别名
Doxepin hydrochloride多虑平 盐酸盐11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride
IUPAC传统名
dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ylidene]propyl})amine hydrochloride
IUPAC标准名
dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ylidene]propyl})amine hydrochloride
化合物性质
产品相关信息
纯度
15% Z-isomer basis
~85% E-isomer basis
≥98% (GC)
安全信息
GHS警示性声明
P301+P310
GHS警示词
Danger
德国WGK号
3
GHS危险声明
H301
RID/ADR
UN 2811 6.1/PG 3
安全公开号
36/37/39-45
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别1,2,3
危险公开号
25
联合国危险货物等级
6.1
个人保护装置
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
联合国危险货物包装类别(PG)
3
欧盟危险性物质标志
有毒 (T)联合国危险货物编号
2811
RTECS编号
HQ4375000
理化性质
溶解度
1 M HCl: soluble50 mg/mL
H2O: soluble
外观
white to off-white powder
药理学性质
相关基因信息
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
描述信息
Other Notes
Mixture of cis- and trans-isomers
Biochem/physiol Actions
Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.
Mixture of cis- and trans-isomers
Biochem/physiol Actions
Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.
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