物质信息
ID:182877
名称和标识
IUPAC标准名
1-(6-{[(1S,10R,11S,14S,15S)-5-methoxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-trien-14-yl]amino}hexyl)-2,5-dihydro-1H-pyrrole-2,5-dione hydrate
别名
U-73122 hydrate1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione
IUPAC传统名
1-(6-{[(1S,10R,11S,14S,15S)-5-methoxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-trien-14-yl]amino}hexyl)pyrrole-2,5-dione hydrate
化合物性质
安全信息
GHS危险声明
H315-H319-H335
安全公开号
26-36
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
保存温度
room temp
GHS警示词
Warning
危险公开号
36/37/38
欧盟危险性物质标志
刺激性 (Xi)GHS警示性声明
P261-P305+P351+P338
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
德国WGK号
3
理化性质
溶解度
H2O: insoluble
ethanol: ~.7 mg/mL
DMSO: ≤2.6 mg/mL (Achieved with heating.)
DMSO: ~.9 mg/mL
chloroform: ~10 mg/mL
ethanol: ≤5 mg/mL (Achieved with heating.)
外观
off-white powder
描述信息
Biochem/physiol Actions
Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.
Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.
分子图谱
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参考文献
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