物质信息

ID:182848

1α,25-Dihydroxyvitamin D3

名称和标识
IUPAC标准名
(1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
IUPAC传统名
calcitriol
别名
1α,25-Dihydroxycholecalciferol1α,25-Dihydroxyvitamin D3Calcitriol
数据登录号
PubChem SID
Beilstein号
化合物性质
安全信息
联合国危险货物包装类别(PG)
1
德国WGK号
3
个人保护装置
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
联合国危险货物等级
6.1
GHS危险品标识
GHS06
急性毒性(口服,皮肤接触,吸入),类别1,2,3
GHS08
呼吸道过敏,类别1
生殖细胞突变,类别1A,1B,2
致癌性,类别1A,1B,2
生殖毒性,类别1A,1B,2
特定目标器官毒性 – 一次接触,类别1,2
特定目标器官毒性 – 反复接触,类别1,2
吸入危险,类别1
欧盟危险性物质标志
剧毒 剧毒 (T+)
安全公开号
36/37/39-45
保存温度
-20°C
RID/ADR
UN 2811 6.1/PG 1
GHS警示性声明
P260-P264-P280-P284-P301+P310-P302+P350
危险公开号
63-26/27/28
GHS警示词
Danger
GHS危险声明
H300-H310-H330-H361
联合国危险货物编号
2811
RTECS编号
FZ4645000
产品相关信息
纯度
≥99% (HPLC)
产品质量级别
PREMIUM
药理学性质
相关基因信息
human ... VDR(7421)
理化性质
溶解度
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描述信息
Frequently Asked Questions
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Biochem/physiol Actions
Biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.
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