物质信息

ID:1826016

名称和标识
IUPAC传统名
ketorolac
IUPAC标准名
5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
别名
ketorolac(+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid(+-)-ketorolacrac-ketorolac
国际非专利药品(INN)
ketorolacketorolacoketorolacum
数据登录号
PubChem CID
DrugBank ID
KEGG ID
Reaxys Registry
ACToR数据库
BKMS React数据库
BRENDA数据库
BRENDA Ligand数据库
CHEMBL
CompTox数据库
MetaboLights数据库
SureChEMBL数据库
HMDB数据库
维基百科标题
KEGG DRUG Database
CHEBI ID
PubChem SID
化合物性质
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描述信息
A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
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