物质信息
ID:182226
名称和标识
IUPAC标准名
1-(2-{[(4-chlorophenyl)methyl]sulfanyl}-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole; nitric acid
IUPAC传统名
acid, nitric; sulconazole
别名
1-(2-[p-Chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazoleSulconazole nitrate salt
化合物性质
安全信息
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
安全公开号
36
危险公开号
22
德国WGK号
3
GHS警示词
Warning
RTECS编号
NI4475000
GHS危险声明
H302
欧盟危险性物质标志
有害性 (Xn)GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
描述信息
Application
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus1. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases2.
Biochem/physiol Actions
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro2.
Sulconazole nitrate is an antifungal medication of the imidazole class. It is used clinically to treat skin infections, such as ringworm, athlete′s foot, jock itch, and sun fungus1. It is used to block ergosterol biosynthesis and to inhibit heme oxygenases2.
Biochem/physiol Actions
Sulconazole blocks biosynthesis of ergosterol by inhibiting fungal cytochrome P450-dependent lanosterol 14-α-demethylase, a mechanism similar among azoles. Sulconazole is a heme oxygenase (HO) inhibitor. It has been shown to inhibit both HO-1 and HO-2 in vitro2.
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