物质信息
ID:182108
名称和标识
IUPAC标准名
(2R,3R,4S,5R)-2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol
IUPAC传统名
5-iodotubercidin
别名
5-Iodotubericidin4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine5-Iodotubericidin7-Iodo-7-deazaadenosine
化合物性质
安全信息
个人保护装置
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
德国WGK号
3
保存温度
2-8°C
理化性质
溶解度
0.1 M NaOH: soluble0.8 mg/mL
DMSO: soluble36 mg/mL
0.1 M HCl: soluble0.7 mg/mL
外观
tan solid
产品相关信息
纯度
≥90%
描述信息
Biochem/physiol Actions
5-Iodotubercidin increases fatty acid oxidation activity and glycogen synthesis in hepatocytes. 5-Iodotubercidin is also a potent inhibitor of adenosine uptake into brain.
Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.1
Caution
Solutions may be stored frozen. Use promptly when thawed and protect from exposure to light.
5-Iodotubercidin increases fatty acid oxidation activity and glycogen synthesis in hepatocytes. 5-Iodotubercidin is also a potent inhibitor of adenosine uptake into brain.
Potent inhibitor of adenosine uptake into brain, and of adenosine kinase and subsequent metabolism of adenine nucleotides. In cultured rat hepatocytes, 5-iodotubercidin inhibits both acetyl-CoA carboxylase and de novo synthesis of fatty acids and cholesterol.1
Caution
Solutions may be stored frozen. Use promptly when thawed and protect from exposure to light.
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