Radicicol from Diheterospora chlamydosporia

名称和标识

IUPAC传统名

(4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.0⁶,⁸]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione

IUPAC标准名

(4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.0⁶,⁸]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione

别名

[1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dioneMonordenRadicicol from Diheterospora chlamydosporia

数据登录号

MDL号

MFCD06795865

PubChem SID

24899351

CAS号

12772-57-5

化合物性质

安全信息

危险公开号

45-46-22-36/37/38

GHS危险品标识

急性毒性（口服，皮肤接触，吸入），类别1,2,3

呼吸道过敏，类别1

生殖细胞突变，类别1A，1B，2

致癌性，类别1A，1B，2

生殖毒性，类别1A，1B，2

特定目标器官毒性 – 一次接触，类别1,2

特定目标器官毒性 – 反复接触，类别1,2

吸入危险，类别1

联合国危险货物包装类别(PG)

德国WGK号

联合国危险货物等级

6.1

GHS危险声明

H301-H315-H319-H335-H340-H350

GHS警示词

Danger

RID/ADR

UN 2811 6.1/PG 3

保存温度

-20°C

欧盟危险性物质标志

有毒 (T)

GHS警示性声明

P201-P261-P301+P310-P305+P351+P338-P308+P313

安全公开号

53-26-45

联合国危险货物编号

2811

理化性质

溶解度

ethanol: soluble10 mg/mL

外观

yellow solid

药理学性质

相关基因信息

human ... HSP90AA1(3320), SRC(6714)rat ... Src(83805)

描述信息

Biochem/physiol Actions
Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.
Caution
Photosensitive

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