物质信息
ID:180559
名称和标识
别名
氯苯甲咪唑1-[(2-氯苯基)二苯甲基]-1H-咪唑克霉唑三苯氯甲咪唑Clotrimazole
IUPAC传统名
lotrimin
IUPAC标准名
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
化合物性质
安全信息
安全公开号
26-36
RTECS编号
NI4377000
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
德国WGK号
3
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
危险公开号
22-36/38
GHS警示词
Warning
GHS危险声明
H302-H315-H319
欧盟危险性物质标志
有害性 (Xn)GHS警示性声明
P305+P351+P338
药理学性质
相关基因信息
human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
描述信息
Biochem/physiol Actions
Specific inhibitor of Ca2+-activated K+ channels. Antifungal azole. Antifungal mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Specific inhibitor of Ca2+-activated K+ channels. Antifungal azole. Antifungal mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
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参考文献
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