物质信息
ID:179248
名称和标识
别名
反式-脱氢雄甾酮普拉睾酮去氢表雄酮脱氢异雄酮雄素-5-烯-3β-醇-17-酮DHEA3β-羟基-5-雄烯-17-酮trans-Dehydroandrosterone
IUPAC传统名
dehydroepiandrosterone
IUPAC标准名
(1S,2R,5S,10R,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-7-en-14-one
化合物性质
安全信息
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves
毒品管制信息
Home Office Schedule 4.2regulated under CDSA - not available from Sigma-Aldrich Canada
GHS警示性声明
P261-P305+P351+P338
GHS警示词
Warning
危险公开号
36/37/38
GHS危险声明
H315-H319-H335
欧盟危险性物质标志
刺激性 (Xi)安全公开号
26-36
德国WGK号
2
GHS危险品标识
急性毒性（口服，皮肤接触，吸入），类别4
皮肤刺激，类别2
眼刺激，类别2
皮肤过敏，类别1
特定目标器官毒性 -一次接触，类别3
RTECS编号
BV8396000
药理学性质
相关基因信息
human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)rat ... Ar(24208)
理化性质
熔点
149-151 °C(lit.)
产品相关信息
纯度
≥99%
描述信息
Biochem/physiol Actions
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.
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