物质信息
ID:179162
名称和标识
IUPAC标准名
3-bromo-7-nitro-1H-indazole
IUPAC传统名
3-bromo-7-nitroindazole
别名
3-Bromo-7-nitroindazole
化合物性质
理化性质
外观
light yellow powder
溶解度
ethanol: soluble25 mg/mL
DMSO: soluble
安全信息
GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
欧盟危险性物质标志
有毒 (T)GHS警示性声明
P201-P308+P313
德国WGK号
3
GHS危险声明
H360
保存温度
2-8°C
GHS警示词
Danger
危险公开号
60
安全公开号
53-22-36/37/39-45
个人保护装置
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
产品相关信息
纯度
≥98% (TLC)
描述信息
Biochem/physiol Actions
A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinsons disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.1
A potent inhibitor of all nitric oxide synthase isoforms. Shows substantial neuroprotective effects against hypoxic damage (such as stroke) and animal models of Parkinsons disease. Crystallographic studies show that inhibition of eNOS is due to an induced cascade of conformation changes that ultimately dissociates the tetrahydrobiopterin cofactor from the enzyme.1
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