物质信息
ID:178581
名称和标识
IUPAC标准名
6-amino-N-{1-[(5-carbamimidamido-1-{2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl}-1-oxopentan-2-yl)carbamoyl]-3-methylbutyl}-2-[2-(3-hydroxy-2-{2-[3-(1H-imidazol-5-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]hexanamide
别名
[D-Lys6]-LH-RH
IUPAC传统名
6-amino-N-[1-({5-carbamimidamido-1-[2-(carbamoylmethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl}carbamoyl)-3-methylbutyl]-2-[2-(3-hydroxy-2-{2-[3-(3H-imidazol-4-yl)-2-[(5-oxopyrrolidin-2-yl)formamido]propanamido]-3-(1H-indol-3-yl)propanamido}propanamido)-3-(4-hydroxyphenyl)propanamido]hexanamide
化合物性质
安全信息
保存温度
-20°C
GHS危险品标识
呼吸道过敏，类别1
生殖细胞突变，类别1A，1B，2
致癌性，类别1A，1B，2
生殖毒性，类别1A，1B，2
特定目标器官毒性 – 一次接触，类别1,2
特定目标器官毒性 – 反复接触，类别1,2
吸入危险，类别1
GHS危险声明
H360
GHS警示性声明
P201-P308+P313
欧盟危险性物质标志
有毒 (T)德国WGK号
3
GHS警示词
Danger
危险公开号
60
安全公开号
53-22-36/37/39-45
个人保护装置
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
产品相关信息
纯度
≥95% (HPLC)
理化性质
外观
powder
药理学性质
相关基因信息
human ... GNRH1(2796)
描述信息
Amino Acid Sequence
pGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH2
Biochem/physiol Actions
LH-RH agonist. It has been conjugated to cytotoxic compounds such as methotrexate (MTX), doxorubicin (DOX), and glutaryl-2-(hydroxymethyl)anthraquinone (G-HMAQ), and together with other conjugated LH-RH analogs comprise a class of targeted chemotherapeutic agents for cancers expressing receptors for LH-RH.
pGlu-His-Trp-Ser-Tyr-D-Lys-Leu-Arg-Pro-Gly-NH2
Biochem/physiol Actions
LH-RH agonist. It has been conjugated to cytotoxic compounds such as methotrexate (MTX), doxorubicin (DOX), and glutaryl-2-(hydroxymethyl)anthraquinone (G-HMAQ), and together with other conjugated LH-RH analogs comprise a class of targeted chemotherapeutic agents for cancers expressing receptors for LH-RH.
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