Prescription only, special restrictions imposed in many countries

Hepatic, by several CYP isozymes

B

Oral

80% in metabolized state: 30% biliary and 50% renal

6 to 26 hours (mean value 14.2 hours in steady state conditions)

60 to 70%

183°C (361.4°F)

0.1889 mg/mL (20°C) in water