物质信息
ID:130816
名称和标识
IUPAC传统名
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-(1H-imidazol-4-yl)propanamido]-5-fluoro-4-oxopentanoate
IUPAC标准名
methyl (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanamido]-5-methoxy-5-oxopentanamido]-3-(1H-imidazol-4-yl)propanamido]-5-fluoro-4-oxopentanoate
别名
Z-Leu-Glu(OMe)-His-Asp(OMe)-FMKZ-LE(OMe)HD(OMe)-FMKZ-Leu-Glu(OMe)-His-Asp(OMe)-Fluoromethylketone
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描述信息
A potent, cell-permeable, and irreversible inhibitor of caspase-9. May also inhibit caspase-4 and caspase-5. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
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参考文献
• Fadeel, B., et al. 1999. Leukemia 13, 719.
• Gamen, S. et al., Exp. Cell. Res., 258(1):223 (2000).
• Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.