物质信息
ID:128499
名称和标识
IUPAC标准名
methyl 3-(2,5-dihydroxyphenyl)prop-2-enoate
别名
Methyl 2,5-dihydroxycinnamateERBSTATIN ANALOG
IUPAC传统名
methyl 3-(2,5-dihydroxyphenyl)prop-2-enoate
数据登录号
CAS号
描述信息
Purity: >98%
Erbstatin is a novel inhibitor of the EGF receptor associated tyrosine kinase1 . It is an unstable compound and is completely inactivated in serum in 30 minutes. Methyl 2,5-dihydroxycinnamate is a stable erbstatin analog retaining activity after a 60 minute incubation. It inhibits EGF receptor associated tyrosine kinase in vitro (IC50 =0.77 μM)2 . Inhibition is competitive with substrate and noncompetitive with ATP.
Erbstatin is a novel inhibitor of the EGF receptor associated tyrosine kinase1 . It is an unstable compound and is completely inactivated in serum in 30 minutes. Methyl 2,5-dihydroxycinnamate is a stable erbstatin analog retaining activity after a 60 minute incubation. It inhibits EGF receptor associated tyrosine kinase in vitro (IC50 =0.77 μM)2 . Inhibition is competitive with substrate and noncompetitive with ATP.
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参考文献
• Imoto, M., et al., Biochem. Int. , 15 : 989 (1987).
• Umezawa, K., et al., FEBS Lett. , 260 : 198 (1990).