物质信息
ID:1118
名称和标识
商标名
ChlofucidQuinolorQuesylCapitrolClofuzidEndiaronQuixalin
别名
DichlorohydroxyquinolineChloroxyquinolineCHQChlorquinolDichloroxinDikhloroskinDichloroquinolinolChloroxine
IUPAC标准名
5,7-dichloroquinolin-8-ol
IUPAC传统名
chloroxine
化合物性质
理化性质
疏水性(logP)
3
描述信息
Drug Groups
approved
Description
Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.
Indication
Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.
Pharmacology
Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.
Toxicity
The toxicological properties of this material have not been investigated.
Affected Organisms
Humans and other mammals
References
•
Malaveille C, Brun G, Bartsch H: Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action. IARC Sci Publ. 1991;(115):261-6.
[Pubmed]
•
Malaveille C, Brun G, Bartsch H: Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites. Mutat Res. 1994 May 1;307(1):141-7.
[Pubmed]
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参考文献
• Malaveille C, Brun G, Bartsch H: Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites. Mutat Res. 1994 May 1;307(1):141-7. Pubmed
• Malaveille C, Brun G, Bartsch H: Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action. IARC Sci Publ. 1991;(115):261-6. Pubmed