Drug Groups

approved

Description

Diflorasone is a topical corticosteroid used to treat itching and inflammation of the skin.

Indication

For relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.

Pharmacology

Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Diflorasone is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.

Toxicity

Topically applied diflorasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).

Affected Organisms

Biotransformation

Metabolized, primarily in the liver, and then excreted by the kidneys.

Absorption

Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.

Protein Binding

Bound to plasma proteins in varying degrees.

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