Substance
ID:945
Names and Identifiers
Brand Name
DihydralParterolTachystinHytakerolAntitanilDHT IntensolDichystrolumCalcamineDygratyl
Synonyms
DihydrotachysterolDihydrotachysterolVitamin D4
IUPAC name
(3Z)-3-{2-[(4E)-1-[(3E)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylcyclohexan-1-ol
IUPAC Traditional name
dihydrotachysterol
Registration numbers
CAS Number
Properties
Physical Property
Hydrophobicity(logP)
7.5
Molecule Details
Drug Groups
approved
Description
A vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem]
Indication
Used for the prevention and treatment of rickets or osteomalacia, and to manage hypocalcemia associated with hypoparathyroidism or pseudohypoparathyroidism. Also used for the treatment of vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis).
Pharmacology
Dihydrotachysterol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. Dihydrotachysterol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. Dihydrotachysterol also increases renal phosphate excretion.
Toxicity
Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
Affected Organisms
Humans and other mammals
Protein Binding
>99%
References
•
DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S.
[Pubmed]
•
Bosch R, Thijssen JH, Duursma SA: Action and metabolism of dihydrotachysterol2. J Steroid Biochem. 1987;27(4-6):829-36.
[Pubmed]
•
Pierides AM: Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981 Apr;21(4):241-56.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Pubmed
• Bosch R, Thijssen JH, Duursma SA: Action and metabolism of dihydrotachysterol2. J Steroid Biochem. 1987;27(4-6):829-36. Pubmed
• Pierides AM: Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981 Apr;21(4):241-56. Pubmed