Substance
ID:934
Names and Identifiers
Brand Name
ChibroxinNoroxin
IUPAC name
1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Synonyms
Norfloxacin
IUPAC Traditional name
norfloxacin
Properties
Physical Property
Hydrophobicity(logP)
2.1
Solubility
1.78E+005 mg/L
Molecule Details
Drug Groups
approved
Description
A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. [PubChem]
Indication
For the treatment of urinary tract infection
Pharmacology
Norfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation
Via liver and kidney
Absorption
Rapid
Half Life
3-4 hours
Protein Binding
10 and 15% (Serum protein binding)
Elimination
Norfloxacin is eliminated through metabolism, biliary excretion, and renal excretion.
Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renal clearance (approximately 275 mL/min).
Renal excretion occurs by both glomerular filtration and tubular secretion as evidenced by the high rate of renal clearance (approximately 275 mL/min).
References
•
Goldstein EJ: Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity. Am J Med. 1987 Jun 26;82(6B):3-17.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Goldstein EJ: Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity. Am J Med. 1987 Jun 26;82(6B):3-17. Pubmed