Substance
ID:932
Names and Identifiers
Brand Name
EchodidePhospholine Iodide
IUPAC name
diethyl {[2-(trimethylazaniumyl)ethyl]sulfanyl}phosphonate
Synonyms
EchothiophatePhospholinePhospholine IodideEchothiophate Iodide
IUPAC Traditional name
echothiophate
Properties
Physical Property
Hydrophobicity(logP)
-2.25
Solubility
Soluble
Molecule Details
Drug Groups
approved
Description
A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
Indication
For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
Pharmacology
Echothiophate Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
Toxicity
Side effects include blurred vision or change in near or distant vision and eye pain.
Affected Organisms
Humans and other mammals
References
•
Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702.
[Pubmed]
•
Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Schmidt KG, Horowitz Y, Buckman G, Segev E, Levinger E, Geyer O: Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. Curr Eye Res. 2010 Aug;35(8):698-702. Pubmed
• Reddy RH: Echothiophate iodide: its use in accommodative esotropia (high Ac/A ratio). Indian J Ophthalmol. 1982 Jul;30(4):225. Pubmed