Substance
ID:848
Names and Identifiers
Brand Name
Selsun Blue Oily FormulaVersel LotionExselHead & Shoulders Intensive Treatment 2 in 1 (Persistent Dandruff Shampoo plus Conditioner in One) Formula Dandruff Lotion ShampooHead & Shoulders Intensive Treatment Regular Formula Dandruff Lotion ShampooSelsunSelsun BlueSelensulfidSelsun Blue Extra Conditioning FormulaExsel Lotion ShampooHead & Shoulders Intensive Treatment Conditioning Formula Dandruff Lotion ShampooSebusanSelsun Blue Regular FormulaGlo-SelSelenium(IV) sulfideSelsun Blue Dry FormulaSelsun Blue Extra Medicated Formula
Synonyms
Selenium DisulfideSeSSelenium sulphideSelenium sulfide red powderSulfur selenideSelenium Sulfide
IUPAC name
sulfaneselone
IUPAC Traditional name
selenium sulfide
Properties
Physical Property
Solubility
Practically insoluble
Molecule Details
Drug Groups
approved
Description
Selenium Sulfide is an antifungal agent as well as a cytostatic agent, slowing the growth of hyperproliferative cells in seborrhea. Selenium Sulfide is the active ingredient often used in shampoos for the treatment of dandruff, seborrheic dermatitis and tinea capitis, a fungal infection that is primarily a disease of preadolescent children.
Indication
For treatment of tinea versicolor, tinea capitis, dandruff and seborrheic dermatitis of the scalp.
Pharmacology
Selenium sulfide is an antifungal agent often used in shampoos for the treatment of dandruff and seborrheic dermatitis. Selenium sulfide is highly active in inhibiting the growth of P. ovale. It is also a proven cytostatic agent, slowing the growth of both hyperproliferative and normal cells in dandruff and seborrheic dermatitis. A 0.6% micronized form of selenium sulfide is also safe and effective for dandruff.
Toxicity
No documented reports of serious toxicity in humans resulting from acute ingestion of selenium sulfide, however, acute toxicity studies in animals suggest that ingestion of large amounts could result in potential human toxicity.
Affected Organisms
Humans and other mammals
Fungi
Bacteria
Absorption
There is no substantial absorption through intact skin. Absorption has been reported in patients with open lesions on the scalp or in patients using a 1% cream on the back - a patient with scalp lesions that used selenium shampoos had a level of selenium sulfide as high as 32 μg/ml in her urine.
References
•
Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4.
[Pubmed]
•
Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Johnson BA, Nunley JR: Treatment of seborrheic dermatitis. Am Fam Physician. 2000 May 1;61(9):2703-10, 2713-4. Pubmed
• Chen C, Koch LH, Dice JE, Dempsey KK, Moskowitz AB, Barnes-Eley ML, Hubbard TW, Williams JV: A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children. Pediatr Dermatol. 2010 Sep-Oct;27(5):459-62. doi: 10.1111/j.1525-1470.2010.01093.x. Epub 2010 Aug 24. Pubmed