Substance
ID:820
Names and Identifiers
Synonyms
Cycrimine hydrochlorideCycrimine
IUPAC name
1-cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
IUPAC Traditional name
cycrimine
Brand Name
Pagitane
Properties
Physical Property
Hydrophobicity(logP)
4
Molecule Details
Drug Groups
approved
Description
Cycrimine is a drug used to reduce levels of acetylcholine to return a balance with dopamine in the treatment and management of Parkinson's disease.
Indication
For treatment and management of Parkinson's disease.
Pharmacology
Cycrimine is a central anticholenergic used in the treatment of the symptoms of Parkinson's disease. It is a drug used to reduce levels of acetylcholine. Acetylcholine is usually in balance with dopamine neurotransmitters, however lower levels of dopamine are present in the brain of patients suffering from Parkinson's disease. By lowering levels of acetylcholine, it is thought that this balance may be restored.
Affected Organisms
Humans and other mammals
Protein Binding
14-21%
References
•
Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9.
[Pubmed]
Molecular Spectra
No Data Available
Click here to submit data
References
• Vedasiromoni JR, Ganguly DK: Cycrimine on rat diaphragm. Arch Int Pharmacodyn Ther. 1976 Jan;219(1):64-9. Pubmed