Substance
ID:754
Names and Identifiers
IUPAC name
3-(2-methoxyphenoxy)propane-1,2-diol
IUPAC Traditional name
@guaifenesin
Synonyms
Glycerol guaiacolateGlyceryl guaiacolateGuaifenesinGuiaphenesinGlyceryl guiacolateGlyceryl guaiacolate etherGlycerin guaiacolateMethoxypropanediolGlycerin monoguaiacol etherMethphenoxydiolGlyceryl guaiacol etherMetfenossidioloGlyceryl guaicolateGlyceryl guaiacolGlycero-guaiacol ethero-Methoxyphenyl glyceryl etherMetossipropandioloGlyceryl guaiacyl ether
Brand Name
Actifed-CFlartussinGlycotussGlytussGnaifenesinGuaiacol glyceryl etherRelaxil GRespilTenntusTenntussTolseronHalotussinHytussMiocainaMyocainMyocaineMyoscainGuaiacuranGuaiacyl glyceryl etherGuaiphenesinGuaiphesinGuajacuranGuanarAeronesinBroncholDiabetic Tussin EXGee-GeeGuaia-romMyorelaxPneumomistRelaxyl-GSinumist-SRGuayanesinGvajaHumibid L.AHustosilMiocurinMuskurelaxCortussinFenesinGuaiacol glycerin etherGuaiacol glycerol etherGuaicol glyceryl etherGuajacol-glycerinaetherAmonidrinAnti-TussBalminil ExpectorantBreonesinCalmylin ExpectorantColrex expectorantTolynTulynPropanosedylRedutonReorganinResilResylRobitussinGuiatussMiorelaxNeurotonNeurotoneOresolOresonEquicolGaiamarGenatussGlycodexGuaicol glycerine etherGuaiphenesineAresolBenylin-ECalmipanCresonDilynDorassinAmonidrenTouro EXTulylUni-tussinNaldecon Senior EXOrganidin NRRespenylRitussinScot-tussin ExpectorantSirotolHustodilHytuss-2XMintosylMucinexMucostopMyoscaineGuaiacolglicerinetereGuaiacuraneGuaiamarGuaianesinGuajamarHumibid Sprinkle
Properties
Physical Property
Hydrophobicity(logP)
0.2
Solubility
50 mg/mL
Molecule Details
Drug Groups
approved
Description
An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]
Indication
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Pharmacology
Guaifenesin is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
Toxicity
LD50 1510 mg/kg (rat, oral)
Affected Organisms
Humans and other mammals
Biotransformation
Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
Absorption
Rapidly absorbed from the GI tract
Half Life
1 hour
External Links
Molecular Spectra
No Data Available
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References
No Data Available
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