Substance
ID:74155
Names and Identifiers
Synonyms
Urapidil hydrochloride
IUPAC name
6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione hydrochloride
IUPAC Traditional name
urapidil hydrochloride
Registration numbers
CAS Number
Properties
Pharmacology Properties
Target
adrenergic receptor
Product Information
Salt Data
hydrochloride
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Cancer
Biological Activity:
Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. [1] Oral urapidil is effective and well tolerated when used as second-line therapy in patients with blood pressure inadequately controlled with other agents. Urapidil has also been demonstrated to ameliorate glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia. Intravenous urapidil is effective in the treatment of hypertensive crises, perioperative hypertension, and pre-eclampsia and may have a potential role in the management of acute stroke. [2]References on Urapidil HCl[1] Am J Cardiol., 1989, 64(7):1D-6D[2] Adv Ther., 2010, 27(7):426-43
Biological Activity:
Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. [1] Oral urapidil is effective and well tolerated when used as second-line therapy in patients with blood pressure inadequately controlled with other agents. Urapidil has also been demonstrated to ameliorate glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia. Intravenous urapidil is effective in the treatment of hypertensive crises, perioperative hypertension, and pre-eclampsia and may have a potential role in the management of acute stroke. [2]References on Urapidil HCl[1] Am J Cardiol., 1989, 64(7):1D-6D[2] Adv Ther., 2010, 27(7):426-43
Molecular Spectra
No Data Available
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References
• Buch J.Adv Ther. 2010; 27(7):426-43.