Substance
ID:740828
Names and Identifiers
IUPAC name
potassium fluoride
IUPAC Traditional name
potassium fluoride
Synonyms
Potassium fluoride, anhydrous氟化钾, 无水
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
Merck Index
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazard Class
6.1
UN Number
UN1812
European Hazard Symbols
Toxic (T)Safety Statements
26-45
Packing Group
III
GHS Precautionary statements
P261-P301+P310-P361-P302+P352-P405-P501A
RTECS
TT0700000
Storage Warning
Hygroscopic
TSCA Listed
是
GHS Hazard statements
H301-H311-H331
Risk Statements
23/24/25
Physical Property
Apperance
Crystalline
Refractive Index
1.363
Melting Point
859°C
Boiling Point
1505°C
Density
2.48
Product Information
Purity
99%
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• KF can also behave as a base in a wide variety of applications:
• Reviews: Fluoride ion as a base in organic synthesis: Chem. Rev., 80, 429 (1980). Alkali metal fluorides in organic synthesis: Synthesis, 169 (1983). See also Cesium fluoride, 12885.
• In the Henry reaction of 1-nitropropane with an aldehyde: Org. Synth. Coll., 9, 242 (1998). For the methylenation of catechols with Dibromomethane, A10456, in DMF: Tetrahedron Lett., 3361 (1976). In an olefination reaction with 2,2,2-Trifluoroacetophenone, A11403: J. Org. Chem., 59, 2898 (1994). In combination with 18-crown-6 for selective removal of Fmoc protecting groups under mild conditions: Synth. Commun., 24, 187 (1994).
• Widely used in "halex" fluorination reactions for the preparation of aryl fluorides from the corresponding chlorides by heating in a dipolar aprotic solvent, e.g. tetramethylene sulfone: J. Fluorine Chem., 46, 529 (1990). Other solvents including DMSO, DMA and NMP are also successfully employed. For a review of the preparation of aryl fluorides by halogen exchange, see: Chem. Ind. (London), 518 (1986). Aryl nitro groups can also be displaced in suitable molecules: J. Org. Chem., 56, 6406 (1991). Relative rates for aromatic fluorodenitration in different solvents were found to be: DMSO > tetramethylene sulfoxide > DMA > NMP > tetramethylene sulfone >> acetonitrile > DME: J. Fluorine Chem., 35, 591 (1987).
• An active form of KF has been prepared by recrystallization from methanol followed by drying at 100oC: Tetrahedron, 51, 6363 (1995).
• For use in trifluoromethylation of aromatic, allylic and ɑ-carboxy halides, see Methyl chlorodifluoroacetate, A18623.
• Has been used in cleavage of silyl protecting groups under phase-transfer conditions (see tert-Butyldimethylchlorosilane, A13064): J. Am. Chem. Soc., 90, 4462, 4464 (1968); 96, 2250 (1974); J. Chem. Soc., Chem. Commun., 514 (1979).