Substance
ID:740
Names and Identifiers
Synonyms
PrednisolonePrednisolona [INN-Spanish]Prednisolone AcetatePrednisolone Sodium PhosphatePRDLPrednisolonum [INN-Latin]Prednisolone TebutateDeltahydrocortisoneMethylprednisolone AcetatePredisolone Sodium Phosphate
IUPAC name
(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
IUPAC Traditional name
prednisolone
Brand Name
CortaloneCotogesicCotoloneDecortin HDeltacortrilDeltasoloneSteraneUltracorten HUltracortene-HPredcor-TbaPredne-DomePreloneScherisolonSoloneSteranParacotolPrecortalonPrecortilonPred FortePredair APredalone 50Fernisolone PHydroretrocortineI-PredInflamase MildKlismacortMedrolAk-TateAlphadrolDecaprednilDelta FDeltacortenolDeltisiloneUltra PredUltracortene-HydrogenAk-PredPrenoloneSupercortisolUlacortNor-Pred T.B.A.Ocu-PredParacortolPredairPredate-50PredniretardFlamasoneHydeltroneHydroretrocortinKey-PredLentosoneM-PredrolDelcortolDepo-MedrolDydeltroneEconopredErbacortErbasonaPrednicenPrednilidermPrednisRolisoneArticulose-50Co-HydeltraPrecortancylPrecortisylPred MildPredate TbaPrednelanPredni-DomeMetacortandraloneMeti-DermMeticorteloneNisoloneOcu-Pred FortePanafcorteloneHostacortin HHydeltraHydeltra-TbaHydrodeltaloneLite PredMedrol AcetateDeltacortril EntericDerpo PdDicortolDonisoloneEstilsonaFernisolone-PSteroloneUltracortene HCodelcortoneCordrolDelta-CortefDelta-StabPredair FortePredalone T.B.A.Predcor-25Predcor-50PredoninPredonineHydrodeltisoneInflamase ForteMetretonOphtho-TateOrapredPediapredDexa-Cortidelt Hostacortin HDi-Adreson FEazolin DEconopred PlusFernisoloneHydeltrasol
Properties
Physical Property
Solubility
223 mg/L
Hydrophobicity(logP)
1
Molecule Details
Drug Groups
approved
Description
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [PubChem]
Indication
For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.
Pharmacology
Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.
Toxicity
LD50=500 mg/kg (oral, rat), short-term side effects include high blood glucose levels and fluid retention. Long term side effects include Cushing's syndrome, weight gain, osteoporosis, glaucoma, type II diabetes and adrenal suppression.
Affected Organisms
Humans and other mammals
Biotransformation
Excreted in the urine as either free or glucoconjugate.
Absorption
Readily absorbed by gastrointestinal tract, peak plasma concentration is reached 1-2 hours after administration.
Half Life
2-3 hours
Protein Binding
Very high (>90%)
External Links
Molecular Spectra
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References
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