Substance
ID:73992
Names and Identifiers
IUPAC Traditional name
trospium chloride
IUPAC name
(1S,3R,5R)-3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-8$l^{5}-azaspiro[bicyclo[3.2.1]octane-8,1'-pyrrolidin]-8-ylium chloride
Synonyms
SancturaTrospium chloride
Registration numbers
CAS Number
Properties
Product Information
Salt Data
chloride
Safety Information
Storage Condition
-20°C
Pharmacology Properties
Target
Muscarinic receptor
Molecule Details
Biological Activity:
Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride (Sanctura) is a quaternary ammonium compound. Trospium chloride (Sanctura), dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. In active-controlled trials, trospium chloride was at least equivalent to immediate-release formulations of oxybutynin and tolterodine in efficacy and tolerability. [1][2][3]References on Trospium chloride (Sanctura)[] Ann Pharmacother, 2009, 43:283-295[] Therapeutics and Clinical Risk Management, 2005, 1(2):157–166
Trospium chloride (Sanctura) is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride (Sanctura) is a quaternary ammonium compound. Trospium chloride (Sanctura), dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. In active-controlled trials, trospium chloride was at least equivalent to immediate-release formulations of oxybutynin and tolterodine in efficacy and tolerability. [1][2][3]References on Trospium chloride (Sanctura)[] Ann Pharmacother, 2009, 43:283-295[] Therapeutics and Clinical Risk Management, 2005, 1(2):157–166
Molecular Spectra
No Data Available
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References
• Guay DR. Ther Clin Risk Manag. 2005 Jun; 1(2):157-67.