Substance
ID:73936
Names and Identifiers
IUPAC name
N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide hydrochloride
Synonyms
BetapaceBetapace AFBerlex LaboratoriesSotalol hydrochloride
IUPAC Traditional name
sotalol hydrochloride
Registration numbers
CAS Number
Properties
Product Information
Salt Data
hydrochloride
Safety Information
Storage Condition
-20°C
Molecule Details
Research Area: Neurological Disease
Biological Activity:
Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. Sotalol definitely distinctly located binding site to interfere with K+ permeation; both enantiomers associated with a rate close to 5 ? 105 /mol/ sec with the open pore thereby flicker-blocking cardiac K(ATP) channels. [1][2]
Biological Activity:
Sotalol (Betapace) is a non-selective beta blocker and a potassium channel blocker with an IC50 of 43 µM. Sotalol definitely distinctly located binding site to interfere with K+ permeation; both enantiomers associated with a rate close to 5 ? 105 /mol/ sec with the open pore thereby flicker-blocking cardiac K(ATP) channels. [1][2]
Molecular Spectra
No Data Available
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References
• Benz I et al. J Membr Biol. 1994 Dec;142(3):309-2