Substance
ID:73868
Names and Identifiers
IUPAC name
(1S,2S,3S,4S,5R,6S,8S,9S,13S,16S,17S)-11-ethyl-3,8-dihydroxy-4,6,16-trimethoxy-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-13-yl 2-acetamidobenzoate hydrobromide
Synonyms
Lappaconite Hydrobromide
IUPAC Traditional name
(1S,2S,3S,4S,5R,6S,8S,9S,13S,16S,17S)-11-ethyl-3,8-dihydroxy-4,6,16-trimethoxy-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-13-yl 2-acetamidobenzoate hydrobromide
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Product Information
Salt Data
Hydrobromide
Molecule Details
Research Area: Inflammation
Biological Activity:
Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg•L-1 to 40 mg•L-1,the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.The inhibitors of P-glycoprotein had obvious effects on the absorption in small intestines.Sodium caprate was the best enhancer that did not cause significant changes in the morphology of the intestinal membrane after intestinal administration as compared with other absorption enhancers. [1][2]
Biological Activity:
Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg•L-1 to 40 mg•L-1,the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.The inhibitors of P-glycoprotein had obvious effects on the absorption in small intestines.Sodium caprate was the best enhancer that did not cause significant changes in the morphology of the intestinal membrane after intestinal administration as compared with other absorption enhancers. [1][2]
Molecular Spectra
No Data Available
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References
• Wang YZ et al. J Tradit Chin Med. 2009 Jun;29(2):141-5.