Substance
ID:73856
Names and Identifiers
IUPAC name
(10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9,10-dihydroanthracen-9-one
Synonyms
BarbaloinAloin(Barbaloin)
IUPAC Traditional name
(10S)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C
Product Information
Salt Data
Free Base
Molecule Details
Research Area: Cancer
Biological Activity:
Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 µM for HeLaS3 cells. It is used as a stimulant-laxative, treating constipation by inducing bowel movements.It also shows a pronounced antiproliferative effect at physiological concentration, causes cell cycle arrest in the S phase, and markedly increases HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 µM, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. [1][2]
Biological Activity:
Aloin(Barbaloin) is a potent tyrosinase inhibitor with an IC50 of 97 µM for HeLaS3 cells. It is used as a stimulant-laxative, treating constipation by inducing bowel movements.It also shows a pronounced antiproliferative effect at physiological concentration, causes cell cycle arrest in the S phase, and markedly increases HeLaS3 cell apoptosis (to 24%). In the concentration range of 20-100 µM, its action was accompanied by remarkable changes in the activity of almost all antioxidant enzymes: MnSOD activity was increased many fold, while CuZnSOD and iNOS activities were inhibited. Moreover, inhibition of CuZnSOD was shown to occur by direct aloin interaction with the enzyme. [1][2]
Molecular Spectra
No Data Available
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References
• Ni??iforovi?? A et al. Cancer Biol Ther. 2007 Aug;6(8):1200-5.